Abstract: Natural killer cells recognize malignant cells through MHC I-independent mechanism, with no requirements of pre-sensitizing and being capable of quick killing target cells, which gives them a strong potential in cancer immunotherapy. Both NK and T cells are effect cells with killing property in the human body, but they are distinct by classification as innate and adoptive immunity, using different mechanisms to recognize the target cells. Additionally, NK cells can regulate T cell response and modulate tumor microenvironments. Therefore, the combination of NK and T cells could produce synergistic effects in cancer immunotherapy with their own properties. Previous clinical studies have shown that NK cell therapy demonstrated satisfactory efficacy and safety in hematologic disorders. This paper reviewed

Key words: natural killer cell, cancer immunotherapy, cell immunotherapy