Journal of University of Science and Technology of China ›› 2018, Vol. 48 ›› Issue (10): 801-809.DOI: 10.3969/j.issn.0253-2778.2018.10.006

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Research advance of NLRP3 inflammasome inhibitor

HE Hongbin   

  1. School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
  • Received:2018-08-01 Revised:2018-09-06 Online:2018-10-31 Published:2018-10-31

Abstract: NLRP3 is an important intracellular pattern recognition receptor, which can form inflammasome with ASC and pro-caspase-1. Formation of NLRP3 inflammasome leads to maturity and secretion of inflammatory cytokines, such as IL-1β and IL-18, and then causes the inflammation. Dysregulation of NLRP3 inflammasome is associated with several human diseases, such as gout, atherosclerosis, neurodegenerative diseases and type 2 diabetes, so NLRP3 inflammasome is a potential target for treatment of those diseases, and several NLRP3 inflammasome inhibitors have shown preventive or therapeutic effects on NLRP3-driven diseases. In this paper the recent research advance of NLRP3 inflammasome inhibitor was briefly reviewed.

Key words: NLRP3 inflammasome, disease, NLRP3 inflammasome inhibitor