Abstract: In recent years, with the rapid development of molecular biology research, increasing attention has been paid to long non-coding RNA (lncRNA) ,whose role in tumor occurrence, development, treatment and prognosis has also been gradually recognized. HULC (highly up-reglated in liver cancer) is a type of lncRNA called liver cancer highly expressed transcript, which was first discovered in liver cancer. Recent studies have revealed that it is also closely related to many other cancers such as gastric cancer, colorectal cancer, osteosarcoma and diffuse large B-cell lymphomas . This paper reviewed the research progress of HULC expression and its mechanism of action in several different tumor tissues.

Key words: lncRNA, highly up-reglated in 1iver cancer （HULC）, tumor