埃洛石纳米管的口服毒性研究

doi:10.3969/j.issn.0253-2778.2017.12.003

中国科学技术大学学报 ›› 2017, Vol. 47 ›› Issue (12): 988-995.DOI: 10.3969/j.issn.0253-2778.2017.12.003

埃洛石纳米管的口服毒性研究

王雪，徐小龙，龚家春，桂宗祥，胡婷婷

中国科学技术大学化学系，安徽合肥 230026）

收稿日期:2017-04-18 修回日期:2017-05-15 出版日期:2017-12-30 发布日期:2017-12-30

Toxicity of halloysite nanotubes in liver of mice after oral administration

WANG Xue, XU Xiaolong, GONG Jiachun, GUI Zongxiang, HU Tingting

Department of Chemistry, University of Science and Technoogy of China, Hefei 230026, China

Received:2017-04-18 Revised:2017-05-15 Online:2017-12-30 Published:2017-12-30
Contact: XU Xiaolong
About author:WANG Xue, female,born in 1990, Master candidate. Research field: bioinorganic chemistry. E-mail:wx1223@mail.ustc.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(21171157,20871111,20571069)

摘要/Abstract

摘要： 埃洛石是一种广泛应用的天然纳米管状材料。研究了纯化后的埃洛石经口服后对小鼠的肝脏的毒性.实验按口服纯化埃洛石的剂量不同分为4组：对照组，4，20和100 mg/kg BW组.实验结果表明，低剂量（4 mg/kg BW）的埃洛石对小鼠的肝脏没有毒性，且可促进小鼠体重增长；而当剂量高于20 mg/kg BW时小鼠的肝脏产生氧化应激反应，体重增长也受到抑制.而且，高剂量的埃洛石还会导致Al在肝脏聚集，并导致肝脏功能障碍和病理变化.

关键词: 埃洛石纳米管, 体内毒性, 肝脏

Abstract: Halloysite is widely used in many fields due to its natural hollow nanotubular structure. To assess the liver toxicity of the purified halloysite nanotubes (HNTs) in mice via oral route, purified HNTs were orally administered to mice at 4, 20 and 100 mg/kg BW body weight (BW) every day for 30 d. Oral administration of HNTs stimulates the growth of the mice at low dose (4 mg/kg BW) with no liver toxicity, but inhibits the growth of the mice and induces oxidative stress in the liver at high dose (≥20 mg/kg BW). In addition, oral administration of HNTs at high dose causes Al accumulation in liver, which induces hepatic dysfunction and histopathologic changes.

Key words: halloysite nanotube, in vivo toxicity, liver

中图分类号:

王雪，徐小龙，龚家春，桂宗祥，胡婷婷. 埃洛石纳米管的口服毒性研究[J]. 中国科学技术大学学报, 2017, 47(12): 988-995.

WANG Xue, XU Xiaolong, GONG Jiachun, GUI Zongxiang, HU Tingting. Toxicity of halloysite nanotubes in liver of mice after oral administration[J]. Journal of University of Science and Technology of China, 2017, 47(12): 988-995.

参考文献

［1］
YUAN P, TAN D, ANNABI-BERGAYA F. Properties and applications of halloysite nanotubes: Recent research advances and future prospects[J]. Applied Clay Science, 2015,112-113: 75-93.
[2] ABDULLAYEV E, LVOV Y. Halloysite clay nanotubes as a ceramic “skeleton” for functional biopolymer composites with sustained drug release[J]. Journal of Materials Chemistry B, 2013,1 (23): 2894-2903.
[3] ZHANG Y, TANG A, YANG H, et al. Applications and interfaces of halloysite nanocomposites[J]. Applied Clay Science, 2015,119:8-17.
[4] VERGARO V, ABDULLAYEV E, LVOV Y M, et al. Cytocompatibility and uptake of halloysite clay nanotubes[J]. Biomacromolecules, 2010,11(3): 820-826.
[5] LAI X, AGARWAL M, LVOV Y M, et al. Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture[J]. Journal of Applied Toxicology,2013, 33 (11): 1316-1329.
[6] ZHANG Y, CHEN Y, ZHANG H,et al.Potent antibacterial activity of a novel silver nanoparticle-halloysite nanotube nanocomposite powder[J].Journal of Inorganic Biochemistry, 2013,118 (1): 59-64.
[7] FAKHRULLINA G I, AKHATOVA F S, LVOV Y M, et al.Toxicity of halloysite clay nanotubes in vivo: A Caenorhabditis elegans study[J]. Environmental Science Nano, 2015, 2 (1): 54-59.
[8] RONG R, XU X L, ZHU S S, et al. Facile preparation of homogeneous and length controllable halloysite nanotubes by ultrasonic scission and uniform viscosity centrifugation[J].Chemical Engineering Journal, 2016, 291: 20-29
[9] MEENA R, PAULRAJ R. Oxidative stress mediated cytotoxicity of TiO2 nano anatase in liver and kidney of Wistar rat[J]. Toxicological & Environmental Chemistry, 2012,94 (1): 146-163.
[10] XU B, XU Z F, DENG Y, et al.Protective effects of Chlorpromazine and Verapamil against cadmium-induced kidney damage in vivo[J]. Experimental & Toxicologic Pathology, 2010, 62 (1): 27-34.
[11] DOBBIE J W, SMITH M J B. Urinary and serum silicon in normal and uremic individuals[J]. iba Found Symp, 1986, 121: 194-213.
[12] ZHANG Y, GAO R, LIU M, et al. Use of modified halloysite nanotubes in the feed reduces the toxic effects of zearalenone on sow reproduction and piglet development[J]. Theriogenology, 2015,83 (5): 932-941.
[13] WANG J, ZHOU G, CHEN C, et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration[J]. Toxicology Letters, 2007, 168 (2): 176-185.
[14] JANI P, HALBERT G W, LANCRIDGE J, et al.Nanoparticle uptake by the rat gastrointestinal mucosa:Quantitation and particle size dependency[J]. Journal of Pharmacy & Pharmacology, 1990, 42 (12): 821-826.
[15] MANKE A, WANG L, ROJANASAKUL Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity[J].BioMed Research International, 2013,2013:942916;doi: 10.1155/2013/942916.
[16] PARK E J, KIM H, KIM Y, et al.Repeated-dose toxicity attributed to aluminum nanoparticles following 28-day oral administration, particularly on gene expression in mouse brain[J]. Toxicological & Environmental Chemistry, 93 (2011) 120-133.
[17] BERTHON G. Chemical speciation studies in relation to aluminium metabolism and toxicity[J]. Coordination Chemistry Reviews,1996, 149(1): 241-280.

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埃洛石纳米管的口服毒性研究

Toxicity of halloysite nanotubes in liver of mice after oral administration

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