NK细胞在肿瘤免疫治疗中的应用

doi:10.3969/j.issn.0253-2778.2018.10.005

中国科学技术大学学报 ›› 2018, Vol. 48 ›› Issue (10): 797-800.DOI: 10.3969/j.issn.0253-2778.2018.10.005

NK细胞在肿瘤免疫治疗中的应用

陈敏华

中国科学院天然免疫与慢性疾病重点实验室，中国科学技术大学免疫学研究所，中国科学技术大学生命科学学院及医学中心，合肥微尺度物质科学国家研究中心，安徽省生物技术药物工程技术研究中心，安徽合肥 230027

收稿日期:2018-07-31 修回日期:2018-08-29 出版日期:2018-10-31 发布日期:2018-10-31
通讯作者: 肖卫华
作者简介:陈敏华，女，1989年生，博士生.研究方向：肿瘤免疫生物学以及NK免疫治疗.E-mail:chenmh@mail.ustc.edu.cn
基金资助:
国家重点基础研究发展（973）计划（2016YFC1303503），中国科学院战略性先导科技专项（B类）

The application of NK cells in tumor immunotherapy

CHEN Minhua

Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, Hefei National Laboratory for Physical Sciences at Microscale, Engineering Technology Research Center of Biotechnology Drugs of Anhui, University of Science and Technology of China, Hefei 230027, China

Received:2018-07-31 Revised:2018-08-29 Online:2018-10-31 Published:2018-10-31

摘要/Abstract

摘要： 自然杀伤细胞(NK细胞)可通过MHC I类分子非依赖地泛特异性识别肿瘤细胞，不需致敏、杀伤快，使其在肿瘤免疫治疗中具有突出的特点和巨大的应用潜力.NK细胞和T细胞为体内的两类具杀伤活性效应的细胞，但分别为天然免疫和获得性免疫细胞，在识别和杀伤肿瘤细胞上各具特点.另外，NK细胞具有调节T细胞免疫应答及肿瘤微环境的作用.因此，特别是在抗肿瘤方面，两者具有优势互补和协同作用.前期研究显示，NK细胞尤其在造血系统恶性肿瘤治疗中展现出突出的疗效及安全性.本文综述了目前NK细胞临床免疫治疗的疗效及应用面临的挑战.相信随着针对NK细胞的免疫治疗技术的突破和药物的开发应用，肿瘤免疫治疗水平必将推向新的高峰.

关键词: 自然杀伤细胞, 肿瘤免疫治疗, 细胞免疫治疗

Abstract: Natural killer cells recognize malignant cells through MHC I-independent mechanism, with no requirements of pre-sensitizing and being capable of quick killing target cells, which gives them a strong potential in cancer immunotherapy. Both NK and T cells are effect cells with killing property in the human body, but they are distinct by classification as innate and adoptive immunity, using different mechanisms to recognize the target cells. Additionally, NK cells can regulate T cell response and modulate tumor microenvironments. Therefore, the combination of NK and T cells could produce synergistic effects in cancer immunotherapy with their own properties. Previous clinical studies have shown that NK cell therapy demonstrated satisfactory efficacy and safety in hematologic disorders. This paper reviewed

Key words: natural killer cell, cancer immunotherapy, cell immunotherapy

陈敏华，王玮，方芳，肖卫华. NK细胞在肿瘤免疫治疗中的应用[J]. 中国科学技术大学学报, 2018, 48(10): 797-800.

CHEN Minhua, WANG Wei, FANG Fang, XIAO Weihua. The application of NK cells in tumor immunotherapy[J]. Journal of University of Science and Technology of China, 2018, 48(10): 797-800.

NK细胞在肿瘤免疫治疗中的应用

The application of NK cells in tumor immunotherapy

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