Journal of University of Science and Technology of China ›› 2015, Vol. 45 ›› Issue (8): 649-654.DOI: 10.3969/j.issn.0253-2778.2015.08.006
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ZENG Bingru
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Abstract: Drug delivery systems can facilitate the delivery of platinum-based drugs, enhance drug efficiency and protect Pt(Ⅳ) from being reduced before cellular uptake. A highly biocompatible Pt(Ⅳ) prodrugs delivery system using calcium phosphate (CaP) nanoparticles with simple preparation procedures were reported. The diameter and morphology of Pt(Ⅳ)/CaP nanoparticles were characterized by dynamic light scattering, scanning electron microscope and X-ray diffraction. Then cellular uptake efficiency and cytotoxicity were studied. The results indicate that nanoparticles are well-dispersive with narrow size distribution; they have high cellular uptake efficiency and redox response so as to release cisplatin after being reduced by cellular reductants. Moreover, the delivery system demonstrates a significantly higher inhibitory effect than the free Pt(Ⅳ) prodrug.
Key words: calcium phosphate nanoparticle, drug delivery system, cisplatin prodrug, Pt(Ⅳ)
ZENG Bingru, SHI Hongdong, LIU Yangzhong. Calcium phosphate nanoparticles for the delivery of the prodrug of cisplatin[J]. Journal of University of Science and Technology of China, 2015, 45(8): 649-654.
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URL: http://just-cn.ustc.edu.cn/EN/10.3969/j.issn.0253-2778.2015.08.006
http://just-cn.ustc.edu.cn/EN/Y2015/V45/I8/649