LncRNA expression profiles of Schizosaccharomyces pombe  in DNA damage inducing environments

doi:10.52396/JUST-2021-0074

Abstract

Abstract: LncRNAs are pervasively transcribed in eukaryotic cells and dynamically regulated in response to environmental changes. Compared to mRNAs, roles of lncRNAs in DNA damage responses are poorly understood. The lncRNA expression profiles of Schizosaccharomyces pombe under the treatment of four kinds of DNA damage generating drugs (camptothecin, hydroxyurea, methyl methanesulfonate and phleomycin) were systematically characterized by RNA-seq. Similar to mRNAs, lncRNA repertoires underwent drastic changes in response to DNA damage inducing environments. A Core DNA Damage Response lncRNA set of 161 commonly induced and 194 commonly repressed lncRNAs was identified. The differences between lncRNA and mRNA transcription profiles suggested that lncRNAs might conduct critical functions in DNA damage responses independent from their associated mRNAs. This profiling on lncRNA expressions provided data and resources for further functional studies of the fission yeast lncRNAs.

Key words: long noncoding RNA, DNA damage, Schizosaccharomyces pombe

CLC Number:

YU Tianyi, WU Ruikun, SHAN Ge, REN Bingbing. LncRNA expression profiles of Schizosaccharomyces pombe in DNA damage inducing environments[J]. Journal of University of Science and Technology of China, 2021, 51(8): 586-597.

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LncRNA expression profiles of Schizosaccharomyces pombe in DNA damage inducing environments

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