关键词: 非小细胞肺癌, EGFR酪氨酸激酶抑制剂, 靶向治疗, 获得性耐药

Abstract: Nowadays, EGFR tyrosine kinase inhibitors (EGFR-TKIs) have become the first-line treatment for non-small cell lung cancer (NSCLC) patients with EGFR-sensitive mutations. However, acquired drug resistance remains an unavoidable bottleneck in clinical application. Herein, the mechanisms of acquired drug resistance were reviewed first, including secondary mutation of EGFR, amplification of MET gene, IGF1R and amplification of HER2. Then, therapeutic

Key words: non-small cell lung cancer, EGFR tyrosine kinase inhibitor, targeted therapy, acquired resistance