中国科学技术大学学报 ›› 2018, Vol. 48 ›› Issue (10): 781-784.DOI: 10.3969/j.issn.0253-2778.2018.10.002

• 原创论文 • 上一篇    下一篇

中性粒细胞外诱捕网在肿瘤形成过程中的作用机制研究

吴德海   

  1. 1.哈尔滨医科大学附属第一医院,黑龙江哈尔滨150081; 2.中国科学技术大学生命科学与医学部,附属第一医院(安徽省立医院),安徽合肥230001
  • 收稿日期:2018-09-06 修回日期:2018-09-26 出版日期:2018-10-31 发布日期:2018-10-31
  • 通讯作者: 刘连新
  • 作者简介:吴德海,男,1988年生,博士生. 研究方向:肝癌发生发展的分子机制. E-mail:tianxiadiyi_12345@126.com

The role of neutrophil extracellular traps in the tumor progression

WU Dehai   

  1. 1. The First Affiliated Hospital of Harbin Medical University, Harbin150081, China; 2. The First Affiliated Hospital of USTC(Anhui Provincial Hospital), Division of Life Sciences and Medicine , University of Science and Technology of China, Hefei230001, China
  • Received:2018-09-06 Revised:2018-09-26 Online:2018-10-31 Published:2018-10-31

摘要: 中性粒细胞诱外捕网(neutrophil extracellular traps, NETs)是一种来源于中性粒细胞的DNA网状结构,能够捕获和杀死病原微生物,从而在宿主防御中发挥重要作用.越来越多的证据表明NETs与肿瘤的进展密切相关,且能够通过多种方式促进肿瘤的复发转移.其临床意义也逐渐突显出来.本综述重点阐述促癌微环境中NETs的形成及促进肿瘤复发转移的机制,并对NETs临床应用价值进行探究.

关键词: 中性粒细胞外诱捕网, 肿瘤, 机制

Abstract: Neutrophil extracellular traps (NETs) are neutrophil-derived DNA structures. They have been shown to trap and kill microorganisms, playing a critical role in host defense. Increasing evidence has shown that NETs have a close relationship with tumor progression. And their contribution to tumor recurrence and metastasis has been demonstrated in a number of studies.Furthermore, the clinical significance of NETs has also been highlighted. In this review, emphasis was laid on the mechanism of the formation of NETs and their role in tumor progression in a cancer promoting microenvironment. In addition, the clinical value of NETs was also explored.

Key words: neutrophil extracellular traps (NETs), tumor, mechanism