Toxicity of halloysite nanotubes in liver of mice after oral administration

doi:10.3969/j.issn.0253-2778.2017.12.003

Journal of University of Science and Technology of China ›› 2017, Vol. 47 ›› Issue (12): 988-995.DOI: 10.3969/j.issn.0253-2778.2017.12.003

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Toxicity of halloysite nanotubes in liver of mice after oral administration

WANG Xue, XU Xiaolong, GONG Jiachun, GUI Zongxiang, HU Tingting

Department of Chemistry, University of Science and Technoogy of China, Hefei 230026, China

Received:2017-04-18 Revised:2017-05-15 Online:2017-12-30 Published:2017-12-30
Contact: XU Xiaolong
About author:WANG Xue, female,born in 1990, Master candidate. Research field: bioinorganic chemistry. E-mail:wx1223@mail.ustc.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(21171157,20871111,20571069)

Abstract

Abstract: Halloysite is widely used in many fields due to its natural hollow nanotubular structure. To assess the liver toxicity of the purified halloysite nanotubes (HNTs) in mice via oral route, purified HNTs were orally administered to mice at 4, 20 and 100 mg/kg BW body weight (BW) every day for 30 d. Oral administration of HNTs stimulates the growth of the mice at low dose (4 mg/kg BW) with no liver toxicity, but inhibits the growth of the mice and induces oxidative stress in the liver at high dose (≥20 mg/kg BW). In addition, oral administration of HNTs at high dose causes Al accumulation in liver, which induces hepatic dysfunction and histopathologic changes.

Key words: halloysite nanotube, in vivo toxicity, liver

CLC Number:

WANG Xue, XU Xiaolong, GONG Jiachun, GUI Zongxiang, HU Tingting. Toxicity of halloysite nanotubes in liver of mice after oral administration[J]. Journal of University of Science and Technology of China, 2017, 47(12): 988-995.

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Toxicity of halloysite nanotubes in liver of mice after oral administration

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