Protective effect of Fe3O4 nanoparticles on cadmium chloride-induced toxicity in the small intestine of mice

doi:10.3969/j.issn.0253-2778.2020.07.003

Abstract

Abstract: Synergistic toxicity from multiple environmental pollutants poses greater threat to humans. Here we evaluated combined toxicity of environment pollutants Fe3O4 nanoparticles (nano-Fe3O4) and cadmium chloride (CdCl2) in the small intestine of mice. The results showed that Fe3O4 nanoparticles (nano-Fe3O4) and CdCl2 have a negative synergistic toxicity in the small intestine of mice. Oral nano-Fe3O4 did not show obvious toxicity in the small intestine of mice. In contrast, oral CdCl2 caused significant oxidative stress in the small intestine of mice. CdCl2-induced oxidative stress resulted in inflammatory response in the small intestine as indicated by the significant increases in the levels of cyclooxygenase-2 and nitric oxide synthase as well as the inflammatory cell infiltration in the small intestinal tissue. Co-exposure to nano-Fe3O4 and CdCl2 significantly attenuated the CdCl2-induced damage in the small intestine through reduction of oxidative stress and inflammatory response.

Key words: nano-Fe3O4, Cd, synergistic toxicity, small intestine

CLC Number:

O157.4

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