Journal of University of Science and Technology of China ›› 2014, Vol. 44 ›› Issue (8): 648-654.DOI: 10.3969/j.issn.0253-2778.2014.08.003
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GAO Shang
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Abstract: The wide applications of zinc oxide (ZnO) and ubiquitous cadmium (Cd) pollution have increased the risk of humans co-exposure to ZnO and Cd. The synergistic toxicity of bulk ZnO and CdCl2 in mice was investigated. Mice were randomly divided into four groups: a control group and three experimental groups (bulk ZnO, CdCl2, bulk ZnO+CdCl2). Bulk ZnO shows low toxicity in mice. In contrast, CdCl2 causes siginificant damage in the liver indicated by severe liver dysfunction and histopathological abnormalities. Although co-exposure to bulk ZnO and CdCl2 has positive synergistic effects on the uptakes of Zn and Cd in the liver, bulk ZnO can significantly alleviate CdCl2-induced damage in the liver. The bulk ZnO-induced metallothionein synthesis and the inhibition of Cd-induced deprivation of tissue Zn by bulk ZnO might play two key roles in the protective effect of bulk ZnO on CdCl2-induced damage in the liver.
Key words: heavy metal, histopathology, synergistic toxicity, intraperitoneal injection
GAO Shang, XU Xiaolong, WANG Shasha, ZHU Shanshan, RONG Rui, LI Bing. Synergistic toxicity of bulk zinc oxide and cadmium chloride in mice[J]. Journal of University of Science and Technology of China, 2014, 44(8): 648-654.
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URL: http://just-cn.ustc.edu.cn/EN/10.3969/j.issn.0253-2778.2014.08.003
http://just-cn.ustc.edu.cn/EN/Y2014/V44/I8/648