Evaluation of pulmonary toxicity of zinc-doped  magnetite nanoparticle in mice  after intragastric administration

doi:10.3969/j.issn.0253-2778.2015.05.004

Journal of University of Science and Technology of China ›› 2015, Vol. 45 ›› Issue (5): 366-372.DOI: 10.3969/j.issn.0253-2778.2015.05.004

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Evaluation of pulmonary toxicity of zinc-doped magnetite nanoparticle in mice after intragastric administration

ZHU Shanshan

Department of Chemistry, University of Science and Technology of China, Hefei 230026, China

Received:2015-03-25 Revised:2015-05-01 Online:2015-05-31 Published:2015-05-31
Contact: XU Xiaolong

Abstract

Abstract: Zn2+ doped magnetite nanoparticles (ZnaFebO4 NPs) have higher magnetic susceptibility than conventional magnetite nanoparticles (Fe3O4 NPs). Dimercaptosuccinic acid (DMSA)-coated Zn0.4Fe2.6O4 nanoparticles (Zn0.4Fe2.6O4 NPs) were synthesized. The pulmonary toxicity of DMSA-coated Zn0.4Fe2.6O4 NPs in mice was evaluated after oral administration for one month. No abnormal activities among the mice were observed in Zn0.4Fe2.6O4 NPs-treated group during the whole experiment process. The accumulation of Fe in the lungs was observed after oral administration of DMSA-coated Zn0.4Fe2.6O4 NPs in mice. The accumulation of Fe in the lungs resulted in an increase of coefficient of lung, but did not cause obvious pulmonary injury, except for a very slight inflammatory response in the tissue. The results show that low toxic DMSA-coated Zn0.4Fe2.6O4 NPs may be used as drug delivery or imaging contrast agents by oral route.

Key words: magnetite nanoparticle, Zn, toxicity, histopathology, intragastric administration

ZHU Shanshan, XU Xiaolong, RONG Rui, LI Bing, WANG Xue. Evaluation of pulmonary toxicity of zinc-doped magnetite nanoparticle in mice after intragastric administration[J]. Journal of University of Science and Technology of China, 2015, 45(5): 366-372.

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Evaluation of pulmonary toxicity of zinc-doped magnetite nanoparticle in mice after intragastric administration

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